Description
Lutein and zeaxanthin are powerful antioxidants belonging to the carotenoid family, naturally found in various fruits and vegetables. These nutrients are particularly renowned for their role in maintaining and improving eye health. The human body does not produce these carotenoids, so it is essential to obtain them through diet or supplements.
Lutein and zeaxanthin are yellow-to-red pigments that are highly concentrated in the macula, a small area of the retina responsible for central vision. They work by filtering harmful high-energy blue wavelengths of light and help protect and maintain healthy cells in the eyes.
Clinical Studies
Methods: 112 patients with early AMD were randomly (1:1:1:1) assigned to receive 10 mg lutein, 20 mg lutein, lutein (10 mg)+zeaxanthin (10 mg), or placebo daily for 2 years. MP optical density (MPOD) was recorded at baseline, 48 weeks and 2 years. Retinal sensitivities were measured by multifocal electroretinogram for peak-to-trough amplitude (N1P1) at baseline and at 48 weeks, and in terms of microperimeter-determined mean retinal sensitivity (MRS) at 48 weeks and 2 years.
Results: Supplementation with lutein and zeaxanthin augmented MPOD significantly in active treatment groups (all p<0.05). N1P1 response densities showed significant increases in ring 1 and ring 2 after 48 weeks of supplementation, while no significant changes were seen in rings 3-6. Significant increases in MRS were detected after supplementation with either 10 or 20 mg lutein, whereas no such increases were seen in the placebo arm.
